I know you are supposed to dance with the one that brought you, but I have to sit on my hands and shut my mouth when I see a team walk up to to line of scrimmage and face a 3 man line when they've got 5 of their own to block those 3 and still throw it short and underneath. A 3 man line is an open invitation to run the ball every play and make them stop you from getting 4+ yds per play if you execute against their 3. Then when they sell out and cheat up for the run, go for the jugular.
Do a little research on Chuck Weatherspoon when he was a running back for U of Houston when they ran the "run and shoot". I'll save you the time, for his career he AVERAGED 8.3 yds per carry on almost 400 attempts w/ 27 TD's. He also had 1,375 reception yds and 8 TD's and was built like a bowling ball not a receiver (5'9" 230#). When defenses backed off to stop the run and shoot they would give the ball to Chuck and he would bust it loose almost every time they did it.