We've lost 6 DBs to the NFL over the past two years. It finally caught up with us. We have a lot of good players back there, but they're young. They didn't know what to do, who to cover, etc. in week two.
It was the perfect storm for Mayfield who was seeking revenge from a year ago. Heck, everyone who has posted in this thread so far could've thrown for 350+ on us a month ago.