The computer will lead you to victory:
| Favorite | Underdog | Spread | Computer's Pick | |
| Kansas | Illinois | 3 | C | |
| Wake Forest | Vanderbilt | 10 | U | |
| Kansas State | Troy | 16 | U | |
| James Madison | Virginia | 6.5 | C | |
| Notre Dame | NC State | 7.5 | C | |
| Utah | Baylor | 7.5 | U | |
| Virginia Tech | Purdue | 3 | C | |
| Colorado | Nebraska | 3 | C | |
| Georgia | Ball State | 42 | U | |
| Miami (OH) | UMass | 6.5 | U | |
| UT San Antonio | Texas State | 13.5 | U | |
| Syracuse | Western Michigan | 23.5 | C | |
| Iowa | Iowa State | 4 | C | |
| Texas A&M | Miami | 4 | C | |
| Michigan | UNLV | 38 | C | |
| UTEP | Northwestern | 1 | U | |
| Ole Miss | Tulane | 7.5 | U | |
| Arkansas | Kent State | 38 | C | |
| Marshall | East Carolina | 4 | C | |
| Washington | Tulsa | 34 | U | |
| North Carolina | Appalachian State | 19.5 | U | |
| Liberty | New Mexico State | 10.5 | C | |
| Oklahoma | SMU | 16.5 | U | |
| Georgia Southern | UAB | 7 | U | |
| Florida Atlantic | Ohio | 4 | C | |
| Louisiana | Old Dominion | 6 | C | |
| Pittsburgh | Cincinnati | 7.5 | U | |
| North Texas | Florida International | 12 | U | |
| Alabama | Texas | 7 | U | |
| Memphis | Arkansas State | 21 | C | |
| Houston | Rice | 10 | C | |
| UCF | Boise State | 3.5 | C | |
| Oregon | Texas Tech | 6.5 | C | |
| Missouri | Middle Tennessee | 20.5 | C | |
| Coastal Carolina | Jacksonville State | 13.5 | U | |
| Georgia State | Connecticut | 3.5 | C | |
| Maryland | Charlotte | 24.5 | U | |
| Minnesota | Eastern Michigan | 20.5 | C | |
| Mississippi State | Arizona | 9 | C | |
| Rutgers | Temple | 8.5 | C | |
| Wisconsin | Washington State | 6 | U | |
| UCLA | San Diego State | 14.5 | U | |
| Air Force | Sam Houston State | 13.5 | C | |
| Florida State | Southern Mississippi | 31 | U | |
| Oklahoma State | Arizona State | 3.5 | U | |
| USC | Stanford | 29 | U | |
| Auburn | California | 6.5 | U |