Depends on what you want to do. If you want to hire a guide and float/drift, then there are excellent opportunities in AR on the White and the Little Red. Big browns are the real draw, but the fishing is good all around. Northern/Central part of the state. If you want to wade, I’d actually tell you to go elsewhere. Not that it can’t be done, but being tailwaters, you are at the mercy of the generating schedules. If you hire a guide, call Jamie Rouse. No better guide in the business. Check out his web page, if you want, before you call
The smokies are great, but mostly small Brookies, smaller browns, and bows are plentiful depending on the stocking schedules. Not sure where you’ve fished there but there are some beautiful spots with ample wade in opportunities. I like the south eastern part of TN for fly fishing. The Hiwassee and the Tellico are beautiful. The Tellico is way more friendly for an inexperienced wader. The Hiwassee is a tailwater, and even when not generating a ton of water, it’s dicey. The Tellico is a beautiful river and the wade in opportunities are endless. There are creeks running off the Tellico that are great fishing too.
Personally, I prefer western NC. Cherokee is a sweet fishing spot. It’s easy wading, the fishing is good, and it’s very scenic once your in the river. Pretty cool to watch Elk cross the stream 30 yards from you. There’s also the Nantahala, Oconaluftee, and Tuckasegee that are great fisheries. You can stay in Bryson City, Cullowhee, really anywhere around there and hit all of those. My favorite is the Davidson River in the Pisgah National Forest. Doesn’t get more scenic that this, and there is ample opportunity to fish for larger browns and bows, as well as getting a little more elevation for Brookies.
One other spot most people don’t know about is Broken Bow, OK. Been there twice this year. Mostly stocker bows, but there are big browns here. Just like anywhere, they’re tough to catch. Guided trips are available through Beavers Bend Fly Shop, and I’m sure others, but I just waded in DIY. Be sure to get off the road a ways. Head down Cardiac Hill and when you get to the river, head left. It’s beautiful, and not something you’d expect to see in SW OK. The hiking can be steep, but the trail is good. Find good holes, match the hatch, and let er rip.
When you are able to head out west to fish, PM me. I know guides in MT, WY, and CO that will put you on fish. Also know spots you can DIY if you want. Hope all that helps.