OT: Daily Covid thread 9/25
- Thread starter Tango Two
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Just went for a mandatory Covid nasal test for a procedure I have on Tuesday. I asked if I was expected to stay inside for 4 days. Her reply was said with a smirk "That would be nice." I asked if my daughter was expected to remain in my home until Tuesday as well and all I got was a confused stare. 
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
Just went for a mandatory Covid nasal test for a procedure I have on Tuesday. I asked if I was expected to stay inside for 4 days. Her reply was said with a smirk "That would be nice." I asked if my daughter was expected to remain in my home until Tuesday as well and all I got was a confused stare.
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
Go outside and you usually do.
Enjoy the weekend!
Oh, I'm sure it will!Just went for a mandatory Covid nasal test for a procedure I have on Tuesday. I asked if I was expected to stay inside for 4 days. Her reply was said with a smirk "That would be nice." I asked if my daughter was expected to remain in my home until Tuesday as well and all I got was a confused stare.
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
Also, good luck with the procedure!
Interesting COVID interview with Dr Scott Atlas:
T-cell immunity?
T-cell immunity?
Masks do not keep you safe. It's a placebo for the dumb.
Doesn't look like he socially distances either.
Cloth masks are especially dangerous.
Doesn't look like he socially distances either.
Am I the only one doubting the validity of this story? Are we about see a whole bunch of prominent Dems "test positive" ?
my grand sons high school teachers were all tested as required--so far after 2 weeks no positives
It depends on why you went for the test. If you are feeling ill, and have symptoms, it's better to quarantine until the results come back so you don't infect others if you have it. If you went for the test for a basic medical procedure or as a requirement for your job you don't need to quarantine until the results come back unless the Dr. asks you to. It's all about context. A few examples: My sister was recently diagnosed with breast cancer and needed to go in for surgery. The oncologist asked her to quarantine after the test and for the week leading up to the surgery, so she did.Just went for a mandatory Covid nasal test for a procedure I have on Tuesday. I asked if I was expected to stay inside for 4 days. Her reply was said with a smirk "That would be nice." I asked if my daughter was expected to remain in my home until Tuesday as well and all I got was a confused stare.
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
A friend of mine was required to take a test for him to go back into the office. He wasn't sick and had no symptoms, so he didn't quarantine.
A player on my daughters youth softball team was around a family member who was positive for Covid. That player can't rejoin the team until a negative test result, or a full 2 week quarantine (as long as she and anyone in the house doesn't show symptoms for 2 weeks).
I guess you'd go to a Podiatrist if you needed a knee operation.
Silly question. Of course you would if he aligned with certain opinions.
Back to back papers from the same lab at Rockefeller University report, what I believe, is a major breakthrough.
They report that 14% of people with serious COVID-19 have very limited type 1 interferon responses due to one of two mechanisms. First, some patients have inborn genetic mutations at one of 13 different genes necessary to make type 1 interferons. And second, even more interesting, some patients' own antibodies actually bind to and destroy their type 1 interferons.
The second mechanism has to be considered when giving convalescent plasma since these interferon neutralizing antibodies would be passed to the person receiving the plasma.
Here are the links from yahoo and from Science:
Overview from Yahoo news
more detail from Science
They report that 14% of people with serious COVID-19 have very limited type 1 interferon responses due to one of two mechanisms. First, some patients have inborn genetic mutations at one of 13 different genes necessary to make type 1 interferons. And second, even more interesting, some patients' own antibodies actually bind to and destroy their type 1 interferons.
The second mechanism has to be considered when giving convalescent plasma since these interferon neutralizing antibodies would be passed to the person receiving the plasma.
Here are the links from yahoo and from Science:
Overview from Yahoo news
more detail from Science
The Mayo Clinic disagrees......
"Can face masks help slow the spread of the coronavirus (SARS-CoV-2) that causes COVID-19? Yes, face masks combined with other preventive measures, such as frequent hand-washing and social distancing, help slow the spread of the virus."
Can face masks protect against COVID-19?
Face masks can help slow the spread of coronavirus disease 2019 (COVID-19). Learn about mask types, which masks to use and how to use them.
www.mayoclinic.org
The Mayo Clinic disagrees......
"Can face masks help slow the spread of the coronavirus (SARS-CoV-2) that causes COVID-19? Yes, face masks combined with other preventive measures, such as frequent hand-washing and social distancing, help slow the spread of the virus."
Can face masks protect against COVID-19?
Face masks can help slow the spread of coronavirus disease 2019 (COVID-19). Learn about mask types, which masks to use and how to use them.
So science doesn't agree.
I have no symptoms. Nurse implied I have to stay away from others so I dont risk being infected between today(test day) and Tuesday(procedure day)
I'm sorry to hear about your sister. Our friend was just diagnosed and starts treatment soon. She has a long road ahead but thankfully prognosis was good.
Thank you. My sisters surgery was a success, and now she started radiation. So far so good.
I hope everything goes well on Tuesday. Positive thoughts.
Thank you... It's just a minor procedure.
Positive vibes sent your way for your sister as she starts her radiation.
The Mayo Clinic disagrees......
"Can face masks help slow the spread of the coronavirus (SARS-CoV-2) that causes COVID-19? Yes, face masks combined with other preventive measures, such as frequent hand-washing and social distancing, help slow the spread of the virus."
Can face masks protect against COVID-19?
Face masks can help slow the spread of coronavirus disease 2019 (COVID-19). Learn about mask types, which masks to use and how to use them.
As does the National Academy of Sciences
Our analysis reveals that the difference with and without mandated face covering represents the determinant in shaping the pandemic trends in the three epicenters. This protective measure alone significantly reduced the number of infections, that is, by over 78,000 in Italy from April 6 to May 9 and over 66,000 in New York City from April 17 to May 9. Other mitigation measures, such as social distancing implemented in the United States, are insufficient by themselves in protecting the public. We conclude that wearing of face masks in public corresponds to the most effective means to prevent interhuman transmission, and this inexpensive practice, in conjunction with simultaneous social distancing, quarantine, and contact tracing, represents the most likely fighting opportunity to stop the COVID-19 pandemic. Our work also highlights the fact that sound science is essential in decision-making for the current and future public health pandemics.
Don't have a subscription so all I can go by is someone with no medical education wrote an opinion piece. Guessing there's more to it.
Now if your Alien Sperm Doctor wrote it, that'd be different.
I had a biopsy done on bone in my right shoulder last month. I had to be at home for 7 straight days before the surgery except for when I had the covid test. I was bored sh$tless. I still let my wife and son live a life and go out. No problems came out of it .Good luck !Just went for a mandatory Covid nasal test for a procedure I have on Tuesday. I asked if I was expected to stay inside for 4 days. Her reply was said with a smirk "That would be nice." I asked if my daughter was expected to remain in my home until Tuesday as well and all I got was a confused stare.
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
Florida lifting all restrictions
Restaurants bars to open 100%
Restaurants bars to open 100%
I like people calling masks "face diapers" . So I guess we can call mask wearers "diaper faces" or maybe they are the new "diaper heads".
A family member was in a similar situation and advised to quarantine until procedure day.Just went for a mandatory Covid nasal test for a procedure I have on Tuesday. I asked if I was expected to stay inside for 4 days. Her reply was said with a smirk "That would be nice." I asked if my daughter was expected to remain in my home until Tuesday as well and all I got was a confused stare.
I hope this post doesn't start the usual preschool bickering between you boys. Uh..oops.. I mean men...
^^^^^racistDon't have a subscription so all I can go by is someone with no medical education wrote an opinion piece. Guessing there's more to it.
Now if your Alien Sperm Doctor wrote it, that'd be different.
#Reportable
I do not mind. I just found it odd that when I asked if my daughter should as well the woman looked at me like I had 5 heads.
Going down to southwest Florida next month. Definitely looking forward to being at the beach.
Makes sense considering DeSantis is making the decision.
After all it's not like Florida had the greatest number of deaths the past 7 days.
Oops, they did.
NYC likely to be shut down again Yeah baby! Speaking of NY, Guvanah Gabbaghoul sure hates science. He doesn't trust the FDA or the vaccine.
No wonder they lead the country by far in deaths.
No wonder they lead the country by far in deaths.
Cool stuff, thanks. As you noted, this finding could explain a lot about why convalescent plasma has had such mixed success and why the very pure new antibody cocktails, which wouldn't contain all the other "stuff" from previously infected patients in their plasma, will hopefully be far more effective.
On a perhaps related note, a paper was just published by the Ridgeback/Merck folks on their oral antiviral EIDD-2801/MK-4482 (remdesivir is only IV), showing two key findings. First, they developed a mouse model with supposedly bona fide human lung tissue that duplicates what has been seen with infectivity and impacts of various human coronaviruses, including SARS, MERS and SARS-CoV-2, meaning it should be a good model to test treatments on. And second, they showed that this antiviral is very effective, in vivo, in preventing CV2 infections, used as a pre-exposure prophylactic (and it's worth noting that many of the antivirals were ineffective in vivo, such as HCQ, despite being active in vitro).
The antiviral is in a phase II human study now, which should be rolling into an expanded phase III study soon. Below is the abstract from the paper - where they also talk about inducing a robust type-1 interferon response. Would be curious of your opinion of the paper. This is the drug they brought me back for to help on with process development, as it's all hands on deck to make huge amounts, at risk, in case the clinical trials are positive.
https://assets.researchsquare.com/files/rs-80404/v1_stamped.pdf
Abstract: All known recently emerged human coronaviruses likely originated in bats. Here, we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV, SARS-CoV-2) and two highly relevant endogenous pre-pandemic SARS-like bat coronaviruses. Virus replication in this model occurs in bona fide human lung tissue and does not require any type of adaptation of the virus or the host. Our results indicate that bats harbor endogenous coronaviruses capable of direct transmission into humans. Further detailed analysis of pandemic SARS-CoV-2 in vivo infection of LoM human lung tissue showed predominant infection of human lung epithelial cells, including type II pneumocytes present in alveoli and ciliated airway cells. Acute SARS-CoV-2 infection was highly cytopathic and induced a robust and sustained Type I interferon and inflammatory cytokine/chemokine response. Finally, we evaluated a pre-exposure prophylaxis strategy for coronavirus infection. Our results show that prophylactic administration of EIDD-2801, an oral broad spectrum antiviral currently in phase II clinical trials for the treatment of COVID-19, dramatically prevented SARS-CoV-2 infection in vivo and thus has significant potential for the prevention and treatment of COVID-19.
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