There are a few things that you need to know about KSU with Wade in the game.
Wade is fundamentally sound. He can score in the post or from the perimeter. He can facilitate the game for his teammates. Brown and company are much better when he is in the game. The only thing keeping him from being more on the national radar is a signature win, and his unselfish play. He is kind of the opposite of every player on your roster.
KSU is a good defensive team. They may not have the athletes that Kentucky does, but they are scrappy and will make you play ugly. Their interior guys are tougher than they are given credit for.
If Wade is limited, I don't see how KSU wins this game. With Wade out, KSU is limited to Barry Brown hero ball. The kid plays hard, and gets a few buckets, but his talent level doesn't match up well with his effort. The other guards can be sped up and forced into committing copious turnovers.
If the game is tight at the end KSU does not finish well in pressure packed environments.