What issues will it cause? It's a real time clinical trial in patients with no other good option for treatment. IF administered in proper doses there is very little risk to the patients from what I've read. I was one to poo poo the jubilation over the prospect of this treatment but I don't see any negatives to allowing Dr.s to use it. We'll know very quickly if there's wide spread success with it. We don't have time to run a full clinical trial.It's being touted for political reasons and you're all falling for it. Will it pan out? Maybe...and hopefully! But until there is scientific evidence proving its efficacy, it stands to create more issues than it solves.
because the 3 letters of the channel he saw it on are Bad, it's Bad.What issues will it cause? It's a real time clinical trial in patients with no other good option for treatment. IF administered in proper doses there is very little risk to the patients from what I've read. I was one to poo poo the jubilation over the prospect of this treatment but I don't see any negatives to allowing Dr.s to use it. We'll know very quickly if there's wide spread success with it. We don't have time to run a full clinical trial.
except all of the drugs in question have gone through their own approval process. They've been deemed safe for other disease processes. This is about effectiveness not safety. We're not sure about the effectiveness. If administered at appropriate doses they should be safe.NIH-guided clinical trials. We have protocols for conducting clinical trials and there are protocols to accelerate those trials when an urgent need arises.
Follow the link below, or look up pictures of "the children of thalidomide," if you need evidence for why it is necessary not to push drugs before they are thoroughly vetted in the populace they are intended to treat. Drugs that are safe for one condition under certain circumstances in certain individuals may be poorly suited for others. Don't try and twist my words into saying we are going to have another thalidomide on our hands. That's not what I'm saying. It's a case study I learned about in a drug discovery class in college. Thalidomide is one of the clear historical lessons that have led to the protocols we have today. We can't forget history. Those who do not learn history are doomed to repeat it.
The thalidomide tragedy
except all of the drugs in question have gone through their own approval process. They've been deemed safe for other disease processes. This is about effectiveness not safety. We're not sure about the effectiveness. If administered at appropriate doses they should be safe.
you're absolutely right.Yes, it has been deemed safe for treatment of malaria, RA, and lupus but where I disagree with you is that it can be assumed to be safe for treating other diseases. "No one should take a drug that has not been proven to be safe and effective for a disease or condition for which it is not approved. There are just so many issues that can arise, from side effects to serious toxicity and death due to possible interactions with other medications and other underlying health conditions."
Could Chloroquine Treat Coronavirus?
In addition, by issues, I mean when the President touts a therapy before it's proven, it can create potentially unnecessary demand for a drug (the hoarding TP effect), thereby creating drug shortages for people who actually need this medicine as part of their clinically-proven treatments (like my father who takes Plaquenil (hydroxychloroquine) with methotrexate to manage his RA).
India has already banned exports of hydroxychloroquine. "Over the past few days, state pharmacy boards in Texas, Ohio, Idaho, and Nevada began restricting who can be prescribed the drugs, after reports of some doctors prescribing the drugs for themselves and their families. Consequently, shortages were reported by the American Society of Health-System Pharmacists, although four manufacturers have since pledged to produce millions of tablets."
India bans export...
Note, I'm quoting and providing sources where possible so that you don't have to take the word of some random guy on a message board. We can all claim to be educated or know someone who is a doctor, or works for the government.
Correct. After the proper (and hopefully accelerated) clinical trials have taken place. But the recommendations coming from our elected officials should be in accordance with the guidance of the institutions we've created in this great country.you're absolutely right.
a new virus should not be treated with anything except what's known to be safe in treating it.
all these very specific quotes followed by 'fish cleaner', which, of course, is not at all what they're talking about.Correct. After the proper (and hopefully accelerated) clinical trials have taken place. Look, if you want to take fish cleaner then do it. But the recommendations coming from our elected officials should be in accordance with the guidance of the institutions we've created in this great country.
I understand all of the those things and have intimate knowledge of the rules regarding prescribing medications. BUT, veterinarians for instance have had for decades some discretion to use medications "off label" in instances where there are no other treatment options available. In fact, empirical usage of medications has been wide spread and largely very successful in animals. I understand the concern about safety but there are protocols that have been used elsewhere in the world and I have seen no reports of ill effects from the medications when given appropriately. RA is not a disease with the kind of acute ramifications of COVID-19 pneumonia. I understand your stance and appreciate your argument. In this case, I think we have much more to gain by allowing the treatment protocol than we have to lose. IF in fact it appears to be effective for instance in New York hospitals, companies will ramp up production of the drugs to meet demand so RA patients will get what they need.Yes, it has been deemed safe for treatment of malaria, RA, and lupus but where I disagree with you is that it can be assumed to be safe for treating other diseases. "No one should take a drug that has not been proven to be safe and effective for a disease or condition for which it is not approved. There are just so many issues that can arise, from side effects to serious toxicity and death due to possible interactions with other medications and other underlying health conditions."
Could Chloroquine Treat Coronavirus?
In addition, by issues, I mean when the President touts a therapy before it's proven, it can create potentially unnecessary demand for a drug (the hoarding TP effect), thereby creating drug shortages for people who actually need this medicine as part of their clinically-proven treatments (like my father who takes Plaquenil (hydroxychloroquine) with methotrexate to manage his RA).
India has already banned exports of hydroxychloroquine. In addition, "Over the past few days, state pharmacy boards in Texas, Ohio, Idaho, and Nevada began restricting who can be prescribed the drugs, after reports of some doctors prescribing the drugs for themselves and their families. Consequently, shortages were reported by the American Society of Health-System Pharmacists, although four manufacturers have since pledged to produce millions of tablets."
India bans export...
Note, I'm quoting and providing sources where possible so that you don't have to take the word of some random guy on a message board. We can all claim to be educated or know someone who is a doctor, or works for the government.
People are afraid because of the media.
Be afraid. Live in fear.
What were the 'experts' saying about the worlds most used pain medication coming from the bark of a tree at the time?yeah, this is not good news. It's playing politics with an unproven therapy.
From the story linked in the tweet:
The Food and Drug Administration on Sunday issued an emergency use authorization for hydroxychloroquine and chloroquine, decades-old malaria drugs championed by President Donald Trump for coronavirus treatment despite scant evidence.
"Let's see how it works," Trump said at a press briefing on Sunday, referencing New York state's efforts. "It may. It may not."
Career scientists have been skeptical of the effort, noting the lack of data on the drugs' efficacy for coronavirus care and worried that it would siphon medication away from patients who need it for other conditions, calling instead for the agency to pursue its usual clinical trials.
"I would like to see who at FDA's [Medical Countermeasures Initiative] signed off on this EUA despite the total lack of scientific evidence that chloroquine/hydroxychloroquine are beneficial in the treatment of COVID-19," tweeted Luciana Borio, who served as FDA's acting chief scientist between 2015 and 2017. "EUA is supposed to be issued when the evidence indicates that benefits outweigh the risks."
So, staying at home is for political reasons? Where's the proofs this is the best method?It's being touted for political reasons and you're all falling for it. Will it pan out? Maybe...and hopefully! But until there is scientific evidence proving its efficacy, it stands to create more issues than it solves.
Hearing rumblings that if this gets really bad a "draft" for any and all health care workers,even retired or those who have left the field, could be enacted. Forcing them all back into service. Does anyone else see this type of thing happening?
And herein lies the lie. Sleeping pills are dangerous, always has been, cures off of them,the same.NIH-guided clinical trials. We have protocols for conducting clinical trials and there are protocols to accelerate those trials when an urgent need arises.
Follow the link below, or look up pictures of "the children of thalidomide," if you need evidence for why it is necessary not to push drugs before they are thoroughly vetted in the populace they are intended to treat. Drugs that are safe for one condition under certain circumstances in certain individuals may be poorly suited for others. Don't try and twist my words into saying we are going to have another thalidomide on our hands. That's not what I'm saying. It's a case study I learned about in a drug discovery class in college. Thalidomide is one of the clear historical lessons that have led to the protocols we have today. We can't forget history. Those who do not learn history are doomed to repeat it.
The thalidomide tragedy
Theyre already asking, then they'll yell,then they'll come and get them. Who better anyways?Hearing rumblings that if this gets really bad a "draft" for any and all health care workers,even retired or those who have left the field, could be enacted. Forcing them all back into service. Does anyone else see this type of thing happening?
Maryland shelter in place tonight. Enforcement is up to $5000 and one year in jail.
I did get my travel pass today but it's not issued by DHS. No expiration date and good for local and national travel restrictions.
Temporarily, it is. Emergency acts places the state as complete authority.Is that legal?
New York (CNN)At Brookdale University Hospital Medical Center in New York, the ICU is at capacity, patient beds line the hallways of the emergency department, and the morgue is overflowing.
Covid-19, Dr. Arabia Mollette said, has turned the Brooklyn-based hospital into "a war zone."
"A medical war zone," Mollette, an emergency room physician at Brookdale Hospital, told CNN. "Every day I come, what I see on a daily basis, is pain, despair, suffering and health care disparities."
This is the reality for many hospitals across New York, which has become the epicenter of the American coronavirus outbreak. As of Sunday evening, there are more than 59,000 confirmed cases in the state, and at least 965 deaths in the state, according to CNN's tally of US cases.
Brookdale Hospital granted CNN rare access on Sunday to view health care workers' fight against Covid-19. The hospital is located in Brownsville, one of the poorest neighborhoods in New York City. The Brooklyn borough is one of the hardest hit by the virus, according to city data.
https://www.cnn.com/2020/03/30/us/brooklyn-hospital-coronavirus-patients-deaths/index.html
I've said it from Day One, you can't trust Chinese government numbers. May as well throw them in the trash.Yup, looks like I was completely wrong, any speculation on growth in cases was based on a gross misrepresentation/understatement by the Chinese, where the cases and deaths are who knows how much higher. Just a terrible situation and all bets are off at this point.
Look at the Holland cruise ship with 4 dead and all of those cases. Damn
Some are estimating just of the the number of cremations that upwards of 50,000 have died. Going to bet it is more than that even.Yup, looks like I was completely wrong, any speculation on growth in cases was based on a gross misrepresentation/understatement by the Chinese, where the cases and deaths are who knows how much higher. Just a terrible situation and all bets are off at this point.
Look at the Holland cruise ship with 4 dead and all of those cases. Damn
They followed down spread, high testing, high hygiene etc. Their people are still susceptible,those who never got it, and nor sure which variant was the most widely spread there. Which may make a difference on how society reacts to it, say, if it's a little harder to get, aggressive testing and hygiene will have greater effect against a variant that may outpace efforts.and nobody in S Korea was to leave their home again
Interesting that the two nations with the best responses (S. Korea and Taiwan) were so close to China. They both learned the lesson, not to listen to China, the hard way, previously.I've said it from Day One, you can't trust Chinese government numbers. May as well throw them in the trash.
I think that is especially true of Taiwan. In Korea's case, they had a lot of problems with MERS and they made a lot of changes in response to that. They were well prepared to handle the next pandemic to come their way.Interesting that the two nations with the best responses (S. Korea and Taiwan) were so close to China. They both learned the lesson, not to listen to China, the hard way, previously.
I think it has more to do with mask use than anything else. Japan hasn't done anything...they haven't tested, they haven't distanced, they haven't locked down and their cases are STILL minimal. But their culture is very hygienic, healthy, and they wear masks at the best of times. The western world decries such measures as basic hygiene, personal health, and looking stupid wearing a mask...and our governments haven't stockpiled them and so they had to spread the myth that masks aren't that useful which has lead people to not wear them. This is a virus MOSTLY spread from mouth to mouth or nose...and then requires basic hand washing...if you stop mouth to mouth transmission and wash hands it can be stopped. America is known to be particularly dirty when it comes to bathroom hygiene and we don't wear masks, even if we lockdown people are going to spread it mouth to mouth at grocery stores or on sidewalks.Interesting that the two nations with the best responses (S. Korea and Taiwan) were so close to China. They both learned the lesson, not to listen to China, the hard way, previously.
New York (CNN)At Brookdale University Hospital Medical Center in New York, the ICU is at capacity, patient beds line the hallways of the emergency department, and the morgue is overflowing.
Covid-19, Dr. Arabia Mollette said, has turned the Brooklyn-based hospital into "a war zone."
"A medical war zone," Mollette, an emergency room physician at Brookdale Hospital, told CNN. "Every day I come, what I see on a daily basis, is pain, despair, suffering and health care disparities."
This is the reality for many hospitals across New York, which has become the epicenter of the American coronavirus outbreak. As of Sunday evening, there are more than 59,000 confirmed cases in the state, and at least 965 deaths in the state, according to CNN's tally of US cases.
Brookdale Hospital granted CNN rare access on Sunday to view health care workers' fight against Covid-19. The hospital is located in Brownsville, one of the poorest neighborhoods in New York City. The Brooklyn borough is one of the hardest hit by the virus, according to city data.
https://www.cnn.com/2020/03/30/us/brooklyn-hospital-coronavirus-patients-deaths/index.html
Wrong.I think it has more to do with mask use than anything else. Japan hasn't done anything...they haven't tested, they haven't distanced, they haven't locked down and their cases are STILL minimal. But their culture is very hygienic, healthy, and they wear masks at the best of times. The western world decries such measures as basic hygiene, personal health, and looking stupid wearing a mask...and our governments haven't stockpiled them and so they had to spread the myth that masks aren't that useful which has lead people to not wear them. This is a virus MOSTLY spread from mouth to mouth or nose...and then requires basic hand washing...if you stop mouth to mouth transmission and wash hands it can be stopped. America is known to be particularly dirty when it comes to bathroom hygiene and we don't wear masks, even if we lockdown people are going to spread it mouth to mouth at grocery stores or on sidewalks.
I would bet the usage easily in the multi billions, but the MSM knows best.Hopefully we can wait another year or two for proper clinical trials on a known drug that's been around 60 years, and has multiple uses (and hundreds of millions of prescriptions) during that time including successful treatment of some viral infections.
Or, we can let doctors take care of their patients how they see fit.
Certainly this drug (like any other used to treat this type of issue) needs to be controlled and decided on by doctor and patient.
The recent complaints of doctors "hoarding" this drug for themselves and their families is fairly telling.
https://www.omaha.com/news/local/an...cle_0fcbc30c-1fc1-5393-8b11-087f71399588.html
Ashford was about to open her Saturday virtual town hall to questions on the video chat service Zoom when someone logged in and started posting explicit images.
“It was a Russian name,” said Eric Aspengren, a spokesman for Ashford’s campaign. “We just shut it down immediately because we didn’t know what was going on.”
I've got my money on Boris being the name.