CDC at it again...what a CF

[thatsbaseball]

https://www.washingtonpost.com/heal...ccine-shot-may-be-scheduled-up-6-weeks-later/

How can they just arbitrarily change the drug companies' directions for use ?

 

[Mobile Bay]

Live under a rock and wear a mask forever plebian. Do as you are told by your masters. Our Chinese overlords have spoken.

 

[patdog]

I don’t see the big deal. The guidelines have never been that you have to get the 2nd shot exactly 21 or 28 days after the 1st, just get it as soon as you can.

 

[thatsbaseball]

I am much more interested in the manufacturers' guidelines than the CDC's. Those idiots have waked up in a new world everyday since this thing started.

 

[Apoplectic_Objurgator]

https://www.washingtonpost.com/heal...ccine-shot-may-be-scheduled-up-6-weeks-later/

How can they just arbitrarily change the drug companies' directions for use ?

in other words, we don't know but post-inauguration we only care about optics

 

[MissStFan87]

I don't understand the outrage here. There's evidence that you can receiver a boost too soon (I believe 21 days is the recommended minimum) but there doesn't seem to be a very clear sweet spot beyond that. 6 weeks doesn't seem like a big deal.

 

[patdog]

I am too. But I just don't see how this is really any different from the manufacturers' guidelines. Get your 2nd shot either 21 or 28 days after your 1st one, and if you can't, get it as soon as you can. All they've done is put a cap on "as soon as you can" and I'm not even sure that's a hard cap. I'm extremely suspicious of the CDC and even more so since Tuesday. But I just don't see this as a big deal.

 

[mstateglfr]

Live under a rock and wear a mask forever plebian. Do as you are told by your masters. Our Chinese overlords have spoken.

How does this at all apply to the topic?

 

[mstateglfr]

First off, post a link to an open article. Not everyone around here is Scrooge Mcducking it like fishwater.
https://www.google.com/amp/s/www.nbcnews.com/news/amp/ncna1255136

Secondly, the CDC is just saying that you should get it as soon as possible if a second shot isn't available right away when its your time.
There is a shortage of vaccine, I hear.

 

[WrapItDog]

The UK is waiting up to 12 weeks for 2nd shot

the U.K. government said initially that a second dose would be given either three or four weeks after the first dose, depending on which vaccine was being given and in line with the dosing regimens tested in clinical trials.However, it is now recommending a gap of up to 12 weeks, in an effort to give more people a first dose – and some initial protection against Covid-19.

 

[Cooterpoot]

They recommended this week that you wear two masks unless it's N95 type.

 

[Bill Shankly]

https://www.washingtonpost.com/heal...ccine-shot-may-be-scheduled-up-6-weeks-later/

How can they just arbitrarily change the drug companies' directions for use ?

They are a bit slow. That's old news. Of course the simpletons who are looking for anything to support their simple view, love it.

 

[thatsbaseball]

Why not just call it what it is. Some drug manufacturers and politicians have made a bunch of promises they can't keep and the CDC (being the political pawn that they are) is trying to cover both of their asses with some recommendations that have not been thoroughly researched.

 

[57stratdawg]

Live under a rock and wear a mask forever plebian. Do as you are told by your masters. Our Chinese overlords have spoken.

^^^ convinced “they stole it”

 

[Maroon Eagle]

Perfect is the enemy of good.

I’m OCD but I’m not so OCD that I’m going to be behaving like Chicken Little just because my scheduled second shot isn’t exactly three weeks to the day as my first one.

 

[DesotoCountyDawg]

Laying that condescending attitude on thick tonight aren't we.

 

[MissStFan87]

Why not just call it what it is. Some drug manufacturers and politicians have made a bunch of promises they can't keep and the CDC (being the political pawn that they are) is trying to cover both of their asses with some recommendations that have not been thoroughly researched.

Or they're attempting to ease the stress that people awaiting their 2nd shot are experiencing. Just check social media comments and you can see the panic from some people because they're a couple of days away from that 21/28-day mark and haven't secured the appointment yet. It's important to let people know they don't have to treat it like a ticking time bomb.

 

[Maroon Eagle]

Who knew so many people would confuse the vaccine process with the plot lines of Fantastic Voyage and Innerspace. **

 

[ronpolk]

It’s really unbelievable that we have learned more about this new virus and new vaccine, which is causing recommendations to change. These damn snowflake liberals at the CDC**

 

[Dawg1976]

Probably a good idea but I'm not doing that.

 

[thatsbaseball]

All I'm asking is to see the studies/research/data that show the vaccines' efficacies after the manufacturer`s recommended dosage intervals vs the new CDC guidelines. Is that too much to ask ? Also is the FDA on board with the CDC recommendations ?

 

[T-TownDawgg]

This is what happens when a 10+ year R+D vaccine development and rollout is done in 8-9 months.

 

[Raiderdawg.sixpack]

This recommendation is 100% to alleviate concerns about vaccine accessibility and to calm the freak out that is building about delays in getting the second dose.



The CDC/WHO looked at the initial data and noted you can extend up to 6 weeks it’s still effective. I think 8% of the Moderna clinical study didn’t get a shot at 28 days. So we have some data ranging from early to up to 2 weeks late. I believe if you are over 4 days early the 2nd dose loses effectiveness, but it’s been a while since I looked at that data.

The FDA won’t officially support a deviation from the approved EUA. Moderna and Pfizer would need to support amendment with a sufficient data set requesting approval to change.

Moral of the story, get the second dose like you are supposed to, but if you are delayed don’t freak out or decide not to get it.

Edited to add: The CDC didn’t recommend going to 6 weeks for the 2nd dose, they said it can be given up to 6 weeks and still work.

 

[ckDOG]

Thanks for your insight.

This recommendation is 100% to alleviate concerns about vaccine accessibility and to calm the freak out that is building about delays in getting the second dose.



The CDC/WHO looked at the initial data and noted you can extend up to 6 weeks it’s still effective. I think 8% of the Moderna clinical study didn’t get a shot at 28 days. So we have some data ranging from early to up to 2 weeks late. I believe if you are over 4 days early the 2nd dose loses effectiveness, but it’s been a while since I looked at that data.

The FDA won’t officially support a deviation from the approved EUA. Moderna and Pfizer would need to support amendment with a sufficient data set requesting approval to change.

Moral of the story, get the second dose like you are supposed to, but if you are delayed don’t freak out or decide not to get it.

Edited to add: The CDC didn’t recommend going to 6 weeks for the 2nd dose, they said it can be given up to 6 weeks and still work.

Voice of reason among a sea of hyperbole and naysayers.

 

[DesotoCountyDawg]

Thank you

 

[ronpolk]

All I'm asking is to see the studies/research/data that show the vaccines' efficacies after the manufacturer`s recommended dosage intervals vs the new CDC guidelines. Is that too much to ask ? Also is the FDA on board with the CDC recommendations ?

Did you actually look for any of that stuff before posting on here?

 

[hdogg]

All I'm asking is to see the studies/research/data that show the vaccines' efficacies after the manufacturer`s recommended dosage intervals vs the new CDC guidelines. Is that too much to ask ? Also is the FDA on board with the CDC recommendations ?

These guys claim that nobody has your answer... and are asking the same. Apparently the 21 days had no magic, it was just to get the trials done. Also a lot of folks think the 1st dose is good enough for most.

https://marginalrevolution.com/marginalrevolution/2021/01/half-doses-as-good-as-full.html
https://marginalrevolution.com/marginalrevolution/2021/01/first-doses-first-show-your-work.html

 

[Raiderdawg.sixpack]

These guys claim that nobody has your answer... and are asking the same. Apparently the 21 days had no magic, it was just to get the trials done. Also a lot of folks think the 1st dose is good enough for most.

https://marginalrevolution.com/marginalrevolution/2021/01/half-doses-as-good-as-full.html
https://marginalrevolution.com/marginalrevolution/2021/01/first-doses-first-show-your-work.html

You’re right, there is nothing magical about 3/4 weeks. A second dose may be effective beyond 6 weeks. A single dose may be effective. We may or may not need boosters annually to maintain immunity. We really don’t know yet.

What we know is Moderna and Pfizer set up a trial w/ 2 doses and it appears effective. Based on their initial data, a 2nd dose doesn’t help that much of its too close to the first shot, but it still seems effective up to 6 weeks. They didn’t provide data past 6 weeks or extensively test single dose strategies - so we don’t know.

I am sure as more people vaccinated and more people miss second doses or get a second dose late, we will see updated recommendations.

 

[ronpolk]

You’re right, there is nothing magical about 3/4 weeks. A second dose may be effective beyond 6 weeks. A single dose may be effective. We may or may not need boosters annually to maintain immunity. We really don’t know yet.

What we know is Moderna and Pfizer set up a trial w/ 2 doses and it appears effective. Based on their initial data, a 2nd dose doesn’t help that much of its too close to the first shot, but it still seems effective up to 6 weeks. They didn’t provide data past 6 weeks or extensively test single dose strategies - so we don’t know.

I am sure as more people vaccinated and more people miss second doses or get a second dose late, we will see updated recommendations.

I’d be about willing to bet the house that if we find out in the future a second shot was not really needed then some on this board will claim deep conspiracy against Trump

 

[Raiderdawg.sixpack]

I’d be about willing to bet the house that if we find out in the future a second shot was not really needed then some on this board will claim deep conspiracy against Trump

It’s possible. The 2 dose setup makes scientific sense. The first dose induces an immune response and you get antibody class switch. You hit it with a second dose while it’s still in the peak and you generate a strong immune response which should produce stronger B/T memory.

Complete guess, but in the first couple months post design, Moderna/Pfizer Tested different dosing in vitro and just ran with whatever gave the best results. It doesn’t mean a single dose or other dosing won’t work, they just never tested it once they went to clinical trials.

 

[Maroon Eagle]

I suspect they went with the best test results so they could roll it out when it got to a good enough point. If they wanted something perfect, they would still be having trials.

Perfect is the enemy of good.

 

[thatsbaseball]

Thank you sir.

 

[Antonio Brown's Foot]

Question- what about those of us who already got COVID?

 

[bulldogcountry1]

So is it better for society as a whole for the max number of people get the first shot ASAP or for the max number of people to get both shots ASAP?

 

[mstateglfr]

All I'm asking is to see the studies/research/data that show the vaccines' efficacies after the manufacturer`s recommended dosage intervals vs the new CDC guidelines. Is that too much to ask ? Also is the FDA on board with the CDC recommendations ?

You aren't just asking that. Your initial post was not, in any way, just asking that.

 

[Raiderdawg.sixpack]

The current guidance is here, including guidance for those that had COVID-19 already.

 

[RivaDawg]

First off, post a link to an open article. Not everyone around here is Scrooge Mcducking it like fishwater.
https://www.google.com/amp/s/www.nbcnews.com/news/amp/ncna1255136

Secondly, the CDC is just saying that you should get it as soon as possible if a second shot isn't available right away when its your time.
There is a shortage of vaccine, I hear.

“Scrooge Mcducking it” made me laugh. Thanks and I’m stealing that!

 

[tbaydog]

This reminds me of the social distancing, 6 ft. rule, 5.5 ft you are in trouble. 10 people gathering, but 11 lookout!

 

[RocketDawg]

CDC now says it's OK to get an "extra dose" from the vial. Have they just been throwing the last dose away?

 

[RogerWilco.sixpack]

Gentlemen

this is not some arbitrary bs. A good vaccine that induces modest immunity can be boostered in the same window. Ask a veterinarian. No government conspiracy here.

https://www.washingtonpost.com/heal...ccine-shot-may-be-scheduled-up-6-weeks-later/

How can they just arbitrarily change the drug companies' directions for use ?