I'd guess that it is not easy. I do know that mid-week games are dictated by the schedules and regional travel of the other other conferences. We have to catch a SunBelt/AAC/SoCon/SWAC team passing through on the way to play a weekend series, or one on the way to one of our series. That really limits our pool there. It's why we almost always play Samford or UAB the mid-week before Auburn/SC/UGA, as they are on the way. In general, that regional approach means we typically have much stronger mid-week opponents because many of the USA/Samford/UABs around us are pretty good mid-major programs.
Scheduling and RPI is about 2 things: 1) Balance. and 2) Winning. If you have balanced schedule you will create a strong RPI (hence our 13 OOC).
If you win, RPI takes care of itself. The only time it matters is if you are on the bubble. And, we should rarely be on the bubble.
Just looking at some Big10 schedules for this year:
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PSU opened the season with three games in Arizona (against Air Force, Grand Canyon University, and KSU), played three games against Indiana State in the Bahamas, and played a three game series at Texas Tech.
Rutgers didn't go south of the Carolinas.
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Minnesota started with three games in Deland FL against Stetson, St. John's, and Ball State before playing four games in Fort Myers FL against Florida Gulf Coast University, the Minnesota Twins (? I guess an exhibition game?), and Northeastern twice.
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Indiana played three games in Jacksonville v. LSU, UCF, and Notre Dame.
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Michigan State played a three game series against UT in Austin.
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Northwestern opened with a 3 game series @ Rice and played a three game series @ Ga Tech.
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Iowa opened with 3 games in Arizona (KSU, Airforce, and Northeastern), played a 3 game series at Florida Atlantic, and played three games in Frisco Texas against Alabama, Houston, and OSU.
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Illinois opened with a 3 game series at USF.
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Michigan opened with four games in Arizona against OSU, Stanford, Arizona, and then OSU again. Then played three games in Arlingon Tx against FSU, Louisville, and KSU. Then a three game series at San Diego. Then a three game series in Malibu v. Pepperdine.
Not sure that tells you anything about how easy it is to schedule early season weekend series with them. Obviously most of them are traveling south for early games. Lots of round robin type weekends in places relatively easy to get to in Arizona or Texas or Florida. Not sure if you have the chance to play 3 against say a USF in south florida if that's not more desirable than playing 3 in Starkville against a team you are likely going to struggle with. Also interesting to see how many of them are playing other northern teams in round robin set ups. I guess that makes sense. I'd much rather play against other cold weather teams that have been limited by weather than go get my teeth kicked in by SEC teams that can more or less practice outside year round with the exception of some cold snaps that are usually less than a week at a time.