OT: Vaccine: 2nd Dose

[dfr1966]

Had my second Pfizer shot Wednesday. Other than a little soreness at the injection site, no side effects. Same experience with my first one

 

[rubaseball78_rivals]

My 89 year old mom got 2nd Moderna shot this week. Absolutely zero reaction to it.

 

[T2Kplus20]

CVS in Flemington!

+1
People are starting to have a lot of success with local CVS stores. I know 2 people that recently walked into the Princeton CVS, pretty late at night, and got vaccine shots on the spot.

We are passed our 2 weeks from the second shot, so we are officially on the other side. LOL!

 

[ClassOf02v.2]

Damn I’m jealous of all of you not getting any reaction to the second dose. I still have a fever (100.8), chills, aches.

 

[rureadyforsomefootball]

Both of us got our Pfizer at the Burlington Mall Mega site. We called Friday, March 26th, stayed on hold for 1 hour, 9:30-10_30 am and had both our appointment's the same day at 4;30pm. I told a friend of ours, who has been on 3 online sites since January, with no success, she called that same Friday, and had a 8:30 am appointment the following day.

 

[T2Kplus20]

Had my second Pfizer shot Wednesday. Other than a little soreness at the injection site, no side effects. Same experience with my first one

Exactly my experience as well with the Pfizer vaccine. My wife felt a little tired after shot #2.

 

[RU#1fan]

Damn I’m jealous of all of you not getting any reaction to the second dose. I still have a fever (100.8), chills, aches.

‘When was your 2nd vaccine?

 

[ClassOf02v.2]

‘When was your 2nd vaccine?

Yesterday morning.

 

[Postman_1]

Was talking to a coworker and his wife got the Moderna vaccine. She got the covid three days after the first shot. Then got her second shot at her scheduled date and after receiving her second shot her right eye stayed closed for three days. Scary stuff.
Both parents and in-laws had both shots with only common side effects. Chills, tiredness and run down for a day or two tops.

 

[RUBOB72]

actually it’s just the opposite. more severe side effects are a signal of a more robust immune response which is why the more severe reactions are generally in younger people and women.


It is not experimental.....the clinical trial patients are being followed since they received the vaccine and so far in 6 months of follow up since the last patient was dosed they have demonstrated at least 6 months of protection in the group that received the vaccine. It is likely going to extend beyond that but they need to keep following the patients to make the claim. There will be a lot of real world evidence as well and it’s highly likely the protection will be quite a bit more than 6 months. You’re co worker is to put it bluntly....an idiot.

A more severe reaction is not proof that one’s immune system is better than someone else’s. All it means is the vaccine is stimulating a response within the body . The majority of people seem to have very less severe responses than vice / versa. Sore arms, some aches , some minor chills or fever and usually short lived. Moderna appears to have more of a severe reaction in some recipients than Pfizer. I don’t buy the theory that the more severe a reaction the better the immune response. Also the immune response and having a robust immune system are different from each other.

 

[theRU]

Got my second dose of Pfizer yesterday morning at 10:30. I was fine all day other than soreness at the injection site. Woke up this morning like I got run over by a truck. Fever, chills, hot, body aches all over, feel like I want to nap every 2 hours. Staying in bed watching the Yankees game and then the Final Four.

I had the same thing. 2nd dose at 130pm yesterday. Same symptoms. By 1pm I feel 100%.

 

[theRU]

actually it’s just the opposite. more severe side effects are a signal of a more robust immune response which is why the more severe reactions are generally in younger people and women.


It is not experimental.....the clinical trial patients are being followed since they received the vaccine and so far in 6 months of follow up since the last patient was dosed they have demonstrated at least 6 months of protection in the group that received the vaccine. It is likely going to extend beyond that but they need to keep following the patients to make the claim. There will be a lot of real world evidence as well and it’s highly likely the protection will be quite a bit more than 6 months. You’re co worker is to put it bluntly....an idiot.

I just want to know how they judge effectiveness when at least 50% of people who get covid don't know show symptoms. Are they all being swabbed daily? Do those people still social d and wear masks? Seems like at a minimum a placebo would prove 60% effective.

Show me a trial where people get the vaccine and walk through a covid wing without any ppe and don't come down with the virus.

 

[ruman]

J&J today. No issues. And I’m done.

 

[WhiteBus]

Moderna 2nd shot Wednesday. Felt great Thursday and went out to watch Yankees and the crossover Phillies innings. Zero side effects.

 

[WhiteBus]

I just want to know how they judge effectiveness when at least 50% of people who get covid don't know show symptoms. Are they all being swabbed daily? Do those people still social d and wear masks? Seems like at a minimum a placebo would prove 60% effective.

Show me a trial where people get the vaccine and walk through a covid wing without any ppe and don't come down with the virus.

What is your issue besides being afraid of getting a shot?

 

[RU#1fan]

Yesterday morning.

I had 2 days of fever after my 1st Pfizer vaccine.
Only yesterday for you is not bad..

 

[phs73rc77gsm83]

Had my first Pfizer shot on March 4. I had a sore arm the first day after about 6 hours that lasted into the next day. My second Pfizer was March 24 Alf about 8 hours afeter I had a low grade fever (range 99.7 to 100.2) for about 20 hours. I was fine after that.

 

[theRU]

What is your issue besides being afraid of getting a shot?

I got my vaccine - I just don't want to be a blind sheep. If these things really don't work I want to know. Lol

 

[T2Kplus20]

I got my vaccine - I just don't want to be a blind sheep. If these things really don't work I want to know. Lol

Look at Israel and the 6-month data just realized by Pfizer. Remember, the clinical trial patients will be tracked for at least 2 years. The are well ahead of us and will be tested to see how long the vaccine works. So far so good!

 

[MulletCork]

I’m almost 2 months out from my 2nd Moderna shot now. Still alive and kicking. Anyone not getting this is being selfish. Glad to see all my normal healthy buddies getting it now.

 

[RC1991]

I just want to know how they judge effectiveness when at least 50% of people who get covid don't know show symptoms. Are they all being swabbed daily? Do those people still social d and wear masks? Seems like at a minimum a placebo would prove 60% effective.

Show me a trial where people get the vaccine and walk through a covid wing without any ppe and don't come down with the virus.

the study was designed to evaluate whether the vaccine was effective against symptomatic COVID as well as severe disease, hospitalizations and death. The protocol is publicly a available.

 

[wheezer]

I had my second shot (Pfizer) about three weeks ago

I went snow skiing the day after both shots, getting up 6 am each of those mornings and just doing it

 

[RC1991]

A more severe reaction is not proof that one’s immune system is better than someone else’s. All it means is the vaccine is stimulating a response within the body . The majority of people seem to have very less severe responses than vice / versa. Sore arms, some aches , some minor chills or fever and usually short lived. Moderna appears to have more of a severe reaction in some recipients than Pfizer. I don’t buy the theory that the more severe a reaction the better the immune response. Also the immune response and having a robust immune system are different from each other.

the immune response is influenced by many factors and it’s been shown that women mount a stronger immune response (and more severe side effects) to the COVID and other vaccines. Likely due to estrogen and other genetic factors since many immune related genes are located on the X chromosome. I didn’t say that people don’t have severe side effects have no or a poor response just that the severe effects seem to be associated with the strongest responses. Moderna may encode for a slightly different piece of viral mRNA than Pfizer and also encapsulates it in a different lipid which can also account for the difference in reactions. And before you ask, yes, I am an immunologist.

 

[Plum Street]

A more severe reaction is not proof that one’s immune system is better than someone else’s. All it means is the vaccine is stimulating a response within the body . The majority of people seem to have very less severe responses than vice / versa. Sore arms, some aches , some minor chills or fever and usually short lived. Moderna appears to have more of a severe reaction in some recipients than Pfizer. I don’t buy the theory that the more severe a reaction the better the immune response. Also the immune response and having a robust immune system are different from each other.

Are you a doctor ?

 

[RUBOB72]

the immune response is influenced by many factors and it’s been shown that women mount a stronger immune response (and more severe side effects) to the COVID and other vaccines. Likely due to estrogen and other genetic factors since many immune related genes are located on the X chromosome. I didn’t say that people don’t have severe side effects have no or a poor response just that the severe effects seem to be associated with the strongest responses. Moderna may encode for a slightly different piece of viral mRNA than Pfizer and also encapsulates it in a different lipid which can also account for the difference in reactions. And before you ask, yes, I am an immunologist.

You touched upon something that definitely has been see with the Moderna vaccine in women. A possible more severe reaction after dose #2 has shown up with fever, chills and general malaise and flu like body aches. All things aside It is disappointing to see that some are still claiming deadly effects from these vaccines . Not impossible but seems quite unlikely.

 

[Knight Ed_rivals]

I did Moderna, No side effects on either dose. Only know one guy who had a reaction on second dose, Flu like symtons the next day. He's 68. I know about a dozen people who have had no symptoms on either dose.

 

[WhiteBus]

I got my vaccine - I just don't want to be a blind sheep. If these things really don't work I want to know. Lol

Who says they don't work besides those that won't want to get it??

 

[theRU]

Who says they don't work besides those that won't want to get it??

So........... this whole conversation is about understanding how they arrive at their efficacy rates. My question is what efficacy rate does the placebo have?

 

[WhiteBus]

So........... this whole conversation is about understanding how they arrive at their efficacy rates. My question is what efficacy rate does the placebo have?

Zero point zero.

 

[TdogRU]

I just want to know how they judge effectiveness when at least 50% of people who get covid don't know show symptoms. Are they all being swabbed daily? Do those people still social d and wear masks? Seems like at a minimum a placebo would prove 60% effective.

Show me a trial where people get the vaccine and walk through a covid wing without any ppe and don't come down with the virus.

the efficacy rates are based on people coming down with symptomatic covid. So just as there’s no data on how many people had asymptomatic covid with the vaccine there’s no data on the numbers of people that had asymptomatic covid with the placebo. Although someone could expect that it would be far higher than the numbers in the vaccine group given the huge disparity between the symptomatic covid numbers.

 

[RU#1fan]

I’m almost 2 months out from my 2nd Moderna shot now. Still alive and kicking. Anyone not getting this is being selfish and not playing with a full deck . Glad to see all my normal healthy buddies getting it now.

FIFY

 

[ClassOf02v.2]

Got my second dose of Pfizer yesterday morning at 10:30. I was fine all day other than soreness at the injection site. Woke up this morning like I got run over by a truck. Fever, chills, hot, body aches all over, feel like I want to nap every 2 hours. Staying in bed watching the Yankees game and then the Final Four.

Woke up this morning, fever gone. Bit of a lingering headache, but overall back to normal.

 

[Mike from MD]

I just want to know how they judge effectiveness when at least 50% of people who get covid don't know show symptoms. Are they all being swabbed daily? Do those people still social d and wear masks? Seems like at a minimum a placebo would prove 60% effective.

Show me a trial where people get the vaccine and walk through a covid wing without any ppe and don't come down with the virus.

The effectiveness of the vaccine is based on the measure of antibodies generated following vaccination.

Antibody titer

 

[RUBOB72]

So it sounds as though if you don’t have a more severe reaction then you will have less protection ? No reaction = No benefit?

 

[rotorocker]

"So it sounds as though if you don’t have a more severe reaction then you will have less protection ? No reaction = No benefit?"

no, please don't spread misinformation

 

[RUBOB72]

"So it sounds as though if you don’t have a more severe reaction then you will have less protection ? No reaction = No benefit?"

no, please don't spread misinformation

It was a question ... not a spreading of misinformation. Where did you cull that from?