Covid 5.0

Status
Not open for further replies.

leodisflowers

Senior
Feb 25, 2011
14,801
808
0
Zinc stopping the replication process in vitro is a lot different than stopping it in the body. It isn't as simple as you make it sound. What most practitioners would say about the drug cocktail being given is that it is adjunct therapy. It doesn't cure the disease so much as it supports the immune system and prevents secondary bacterial infections from overwhelming the patient. The other consideration is that ALL of those things taken in inappropriate amounts can cause great harm.

So don't drink the fish tank cleaner? Tastes so good with a hint of gin...
 

MOHUSKER

All-Conference
Nov 1, 2009
16,561
1,806
113
Got contacted by an old employee at a hospital I worked for, they are building a 50 bed unit in a parking garage in prep for patients coming in. I remember having to prep to build those for Ebola and H1N1, but they never came, sounds like this time it’s happening.
 

HUSKERFAN66

All-Conference
Dec 8, 2004
21,241
3,579
113
Zinc stopping the replication process in vitro is a lot different than stopping it in the body. It isn't as simple as you make it sound. What most practitioners would say about the drug cocktail being given is that it is adjunct therapy. It doesn't cure the disease so much as it supports the immune system and prevents secondary bacterial infections from overwhelming the patient. The other consideration is that ALL of those things taken in inappropriate amounts can cause great harm.
True but they all have benchmarks and many years of data on them by themselves
 
Jan 9, 2011
932
316
0
Interesting. Wonder what dosage, timing others are using.
Zinc stops the replication process
Hydrochloroquine forces the zinc into the cells
Azithro kills opportunistic bacteria.
My understanding is that the mechanism of action for hydroxychloroquine is that it acidifies the lumen of endosomes through which malarial parasites (remember this is an anti-malarial drug) enter the cells. Because coronaviruses enter through means other than endocytosis these drugs predictably should have little effect. At high doses, which are lethal in humans, they may help fight the virus, but then what's the point if the drugs themselves kill you.
 

HUSKERFAN66

All-Conference
Dec 8, 2004
21,241
3,579
113
My understanding is that the mechanism of action for hydroxychloroquine is that it acidifies the lumen of endosomes through which malarial parasites (remember this is an anti-malarial drug) enter the cells. Because coronaviruses enter through means other than endocytosis these drugs predictably should have little effect. At high doses, which are lethal in humans, they may help fight the virus, but then what's the point if the drugs themselves kill you.
I guess they better get ahold of the Dr in France and find out what he used in his trial. Although a small trial.
 

RedMyMind

All-Conference
Aug 22, 2017
12,390
1,506
0
My understanding is that the mechanism of action for hydroxychloroquine is that it acidifies the lumen of endosomes through which malarial parasites (remember this is an anti-malarial drug) enter the cells. Because coronaviruses enter through means other than endocytosis these drugs predictably should have little effect. At high doses, which are lethal in humans, they may help fight the virus, but then what's the point if the drugs themselves kill you.
from what I've heard, hydroxychloroquine can possibly act as an ionophore, transporting zinc through the cell membrane much more easily.
 

Ewooc

All-Conference
Nov 29, 2010
6,114
3,053
0
My understanding is that the mechanism of action for hydroxychloroquine is that it acidifies the lumen of endosomes through which malarial parasites (remember this is an anti-malarial drug) enter the cells. Because coronaviruses enter through means other than endocytosis these drugs predictably should have little effect. At high doses, which are lethal in humans, they may help fight the virus, but then what's the point if the drugs themselves kill you.
Yes it is an anti malaria drug but it is used to suppresses the immune system. Is used for rheumatoid arthritis. My mom and uncle have been on it for years for that purpose.
The reason this drug is showing promise is because it suppresses the immune system. Many of the patients who are crashing hard from this virus is because their immune systems are going on over drive mode to try and fight the virus. In doing so it gets out of wack and start attacking healthy cell as well.IE Causing lung tissue to be inflamed, the lungs filling with fluid and death.
By suppressing the immune system, Im assuming this helps in stopping that haywire immune system response
 

mwulf

All-Conference
Dec 15, 2013
8,787
1,641
0
The joke Ive seen passed around is the best way to determine if you have the virus is to cough in the face of a rich person and wait for their results to see if you have the virus
 
Jan 9, 2011
932
316
0
Yes it is an anti malaria drug but it is used to suppresses the immune system. Is used for rheumatoid arthritis. My mom and uncle have been on it for years for that purpose.
The reason this drug is showing promise is because it suppresses the immune system. Many of the patients who are crashing hard from this virus is because their immune systems are going on over drive mode to try and fight the virus. In doing so it gets out of wack and start attacking healthy cell as well.IE Causing lung tissue to be inflamed, the lungs filling with fluid and death.
By suppressing the immune system, Im assuming this helps in stopping that haywire immune system response
Correct. My dad is also on it (Plaquenil, which is hydrochloroquine, and he takes it with methotrexate for his RA). The mechanism of action for how it helps with RA is unknown to the best of my knowledge but like most RA treatments it takes months to go into effect so I'm not sure how well it will translate to treating Covid-19.
 
Sep 23, 2005
18,868
3,621
0
The proliferation of testing in Korea was a huge part of getting that under control there. But there are also reasons why that works there so well but wouldn't be as effective here.
 

Solana Beach Husker

All-Conference
Aug 7, 2008
14,102
1,245
0

There are already "old" vaccines that are effective against viruses, such as the old TB vaccine. If there was investment this old TB vaccine could be a new more effective universal vaccine that provides a 50-60% immune boost...which would cut the death rate in half, and cut hospitalizations by 50%. By the time the TB vaccine is even tested 50-100k people will die world-wide when we could have had the industrial plans ready to go once we had community spread. The TB vaccine will be used and will decrease hospitalizations by 25% but investment means improvement. Sadly our greatest inventions of the last 15 years have been smartphones, long-distance shopping, and an electric car that has hundreds of cell phone batteries jammed inside of it....
 
Jan 10, 2020
8,138
0
0
There are already "old" vaccines that are effective against viruses, such as the old TB vaccine. If there was investment this old TB vaccine could be a new more effective universal vaccine that provides a 50-60% immune boost...which would cut the death rate in half, and cut hospitalizations by 50%. By the time the TB vaccine is even tested 50-100k people will die world-wide when we could have had the industrial plans ready to go once we had community spread. The TB vaccine will be used and will decrease hospitalizations by 25% but investment means improvement. Sadly our greatest inventions of the last 15 years have been smartphones, long-distance shopping, and an electric car that has hundreds of cell phone batteries jammed inside of it....
did you see the news about Ford producing much-needed medical equipment?

the rich get richer amirite
 

Solana Beach Husker

All-Conference
Aug 7, 2008
14,102
1,245
0
Some facts:





This is not the definition of a fact: State and local governments are being panicked into horrific decision-making by garbage models that have already been proven to be wildly wrong.

Your boy sean does not understand exponential growth...I am surprised he didn't put New York up there. And you have to be a sick human being use what should be viewed as "good" news as means to politically attack others...I mean what if social distancing has worked? Doesn't this support this idea?
 

Solana Beach Husker

All-Conference
Aug 7, 2008
14,102
1,245
0
did you see the news about Ford producing much-needed medical equipment?

the rich get richer amirite

You should read the sick stuff that went on World War II with American companies...Jews being shipped to concentration camps in American made transports as the private industry had to be forced to stop working with Nazi Germany. There is a sort of relief that there are companies that have the capital to weather this storm, they work as sort of mini-governments , such as walmart, has the capacity to adjust on the fly, as does Amazon, and do other large manufacturers. They should be paid very well because they are going to be saving lives...
 

MOHUSKER

All-Conference
Nov 1, 2009
16,561
1,806
113
Italy's deaths spiked again a bit, cases are down, but they've dropped to only testing severe cases. Their head of the Civil Protection Agency estimates only 10% of cases have been certified, meaning he expects they have 700K+ cases.
 

Husker.Wed._rivals

All-Conference
Feb 13, 2004
17,651
3,706
98
OMG. If I become ill and end up on a respirator built by Ford all I will be thinking about is to old saying Ford stands for "fix or repair daily". However, my wife's Explorer seems to be holding up real well.
 

NorthWillRiseAgain

All-Conference
Dec 14, 2004
8,760
4,757
113
OMG. If I become ill and end up on a respirator built by Ford all I will be thinking about is to old saying Ford stands for "fix or repair daily". However, my wife's Explorer seems to be holding up real well.
My seat fan seems to last forever. Now if they make life saving equipment out of their paint quality on my truck, we’re all screwed.
 

Headcard

Heisman
Feb 2, 2005
192,509
20,878
113
OMG. If I become ill and end up on a respirator built by Ford all I will be thinking about is to old saying Ford stands for "fix or repair daily". However, my wife's Explorer seems to be holding up real well.
I could see some of those guys with the Kenny pissing on Ford bumper stickers deciding to just take their chances with the virus.
 

Solana Beach Husker

All-Conference
Aug 7, 2008
14,102
1,245
0
Yes it is an anti malaria drug but it is used to suppresses the immune system. Is used for rheumatoid arthritis. My mom and uncle have been on it for years for that purpose.
The reason this drug is showing promise is because it suppresses the immune system. Many of the patients who are crashing hard from this virus is because their immune systems are going on over drive mode to try and fight the virus. In doing so it gets out of wack and start attacking healthy cell as well.IE Causing lung tissue to be inflamed, the lungs filling with fluid and death.
By suppressing the immune system, Im assuming this helps in stopping that haywire immune system response

Zinc disrupts RNA replication of the virus in the cytoplasm. In vitro studies show that zinc inhibits RdRP. The RdRP is necessary for the virus to replicate because it is responsible for making the mRNA (+ and -) and also contributes to the making of the viral membrane and receptors that are necessary for the virus to leave your cell. Zinc is very effective in vitro and has been effective in emergency cases in South Korea and possibly France. This is the disagreement between Drump and Fauci...Trump doesn't understand that a test tube study is not the same as a human study, Fauci needs human trials before he'll o.k it for widespread use.
 

NebChicago

Sophomore
Oct 14, 2009
3,565
141
0
My company just announced 50% salary reductions instead of mass layoffs. Hopefully this is temporary. It's getting real
 

RedMyMind

All-Conference
Aug 22, 2017
12,390
1,506
0
My company just announced 50% salary reductions instead of mass layoffs. Hopefully this is temporary. It's getting real
seems 2 possibilities are going to happen.
Mass infection and the results that come
Mass unemployment and the results that come.
Or both
 
Status
Not open for further replies.