I live in Charlotte.
Not sure how crazy the hotel prices are but imo, if I were coming for the game, I'd stay in Uptown/downtown or Southpark (near the mall not on/near Tyvola).
I'd avoid the airport hotels. And anything on 85 if at all possible.
Yes Uber is here, as is Lyft.
This ^^^
Staying at the Doubletree by Southpark and will drive to the game. There seemed to be decent parking around (due south of the stadium) based on the Panthers games I have attended.
Uptown, renamed from Downtown to promote a new image of the area, certainly has a big city feel to it. We would typically find our way to EpiCenter when in that part. We would usually eat at NIX, now called Cowbell.
Our group will likely head to NoDa after the game for dinner (Cabo Fish Taco) and then to NoDa Brewing. Other breweries in this area include Birdsong, Heist and Free Range.
Around Southpark are plenty of dining spots, more national names. Cowfish in the area gets a bunch of press but I have never personally visited. Taco Mac for a watering hole.
Others that we would frequent: Duckworth's (on Park) for beer, Mac's (on South) for BBQ, there's also plenty of places in Dilworth around East at Scott. Pinky's is a good burger spot on the outskirts of Uptown.